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He, Chuan

One or more keywords matched the following properties of He, Chuan

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overview	Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

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overview

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item Type	Name
Concept	Amino Acid Sequence
Concept	Base Sequence
Concept	Genes, Regulator
Concept	Genetic Techniques
Concept	Genes, Bacterial
Concept	Oncogenes
Concept	Fourier Analysis
Concept	Lead
Concept	Models, Molecular
Concept	Models, Genetic
Concept	Molecular Sequence Data
Concept	Repetitive Sequences, Nucleic Acid
Concept	Nucleic Acid Conformation
Concept	Operon
Concept	Genetic Markers
Concept	Spectrum Analysis
Concept	Transcription, Genetic
Concept	Genome
Concept	Sequence Homology, Amino Acid
Concept	Genetic Variation
Concept	Leukemia, Myeloid
Concept	Gene Library
Concept	RNA Splice Sites
Concept	Genes, Tumor Suppressor
Concept	Genome, Bacterial
Concept	Molecular Conformation
Concept	Leukemia, Myeloid, Acute
Concept	Sequence Analysis, DNA
Concept	Genes, Reporter
Concept	Consensus Sequence
Concept	Evolution, Molecular
Concept	Molecular Chaperones
Concept	Genetic Association Studies
Concept	Histone Code
Concept	Microarray Analysis
Concept	Oligonucleotide Array Sequence Analysis
Concept	Catalytic Domain
Concept	Databases, Genetic
Concept	Promoter Regions, Genetic
Concept	Regulatory Elements, Transcriptional
Concept	Molecular Imaging
Concept	Molecular Structure
Concept	Genome, Human
Concept	Metabolic Networks and Pathways
Concept	Structural Homology, Protein
Concept	Transcriptome
Concept	Molecular Sequence Annotation
Concept	Cloning, Molecular
Concept	Enhancer Elements, Genetic
Concept	Epistasis, Genetic
Concept	Genetic Testing
Concept	Conserved Sequence
Concept	Sequence Analysis, RNA
Concept	Regulon
Concept	Polymorphism, Single Nucleotide
Concept	Protein Array Analysis
Concept	Quantitative Trait Loci
Concept	Epigenesis, Genetic
Concept	Cystine Knot Motifs
Concept	Molecular Dynamics Simulation
Concept	Nucleotide Motifs
Academic Article	Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691.
Academic Article	Intramolecular amide bonds stabilize pili on the surface of bacilli.
Academic Article	Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article	Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article	A selective fluorescent probe for carbon monoxide imaging in living cells.
Academic Article	Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.
Academic Article	The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article	Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Academic Article	The structure of the human AGT protein bound to DNA and its implications for damage detection.
Academic Article	A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article	Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.
Academic Article	Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article	Binding of ReO4(-) with an engineered MoO4(2-)-binding protein: towards a new approach in radiopharmaceutical applications.
Academic Article	Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article	FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article	A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article	Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.
Academic Article	Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article	Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article	Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article	The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.
Academic Article	Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.
Academic Article	Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
Academic Article	Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article	Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Academic Article	An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.
Academic Article	Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article	A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
Academic Article	Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Academic Article	AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.
Academic Article	Dynamic RNA modifications in posttranscriptional regulation.
Academic Article	Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article	Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article	Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article	High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.
Academic Article	N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article	The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article	Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
Academic Article	A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.
Academic Article	Silver-catalyzed intermolecular amination of C--H groups.
Academic Article	Chemical methods to study protein-nucleic acid interactions.
Academic Article	Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article	Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
Academic Article	Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article	Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions.
Academic Article	Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Academic Article	Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Academic Article	Nucleic acid modifications with epigenetic significance.
Academic Article	Mapping recently identified nucleotide variants in the genome and transcriptome.
Academic Article	Selective recognition of metal ions by metalloregulatory proteins.
Academic Article	Direct reversal of DNA alkylation damage.
Academic Article	Reversible RNA adenosine methylation in biological regulation.
Academic Article	Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article	Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Academic Article	Nucleic acid oxidation in DNA damage repair and epigenetics.
Academic Article	Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2.
Academic Article	In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.
Academic Article	Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article	Gold-catalyzed organic transformations.
Academic Article	Synthesis of a FTO inhibitor with anticonvulsant activity.
Academic Article	Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Academic Article	Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor.
Academic Article	Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Academic Article	Modeling non-heme iron proteins.
Academic Article	Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article	Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
Academic Article	Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
Academic Article	A protein engineered to bind uranyl selectively and with femtomolar affinity.
Academic Article	Selective recognition of americium by peptide-based reagents.
Academic Article	RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article	Efficient and quantitative high-throughput tRNA sequencing.
Academic Article	Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article	DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Academic Article	Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing.
Academic Article	Detecting hepatocellular carcinoma in blood.
Academic Article	RNA epigenetics--chemical messages for posttranscriptional gene regulation.
Academic Article	The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article	Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article	Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Academic Article	Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article	A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Academic Article	Evolution of transcript modification by N6-methyladenosine in primates.
Academic Article	DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article	Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article	RNA modifications modulate gene expression during development.
Academic Article	Epigenetics: Making your mark on DNA.
Academic Article	FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
Academic Article	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article	Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Grant	Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma
Academic Article	Special Issue on Regulating the Central Dogma.
Academic Article	Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article	Detailed modeling of positive selection improves detection of cancer driver genes.
Academic Article	Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Academic Article	RADAR: differential analysis of MeRIP-seq data with a random effect model.
Academic Article	N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
Academic Article	DNA 5-Methylcytosine-Specific Amplification and Sequencing.
Academic Article	Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability.
Academic Article	Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
Academic Article	LEAD-m6 A-seq for Locus-Specific Detection of N6 -Methyladenosine and Quantification of Differential Methylation.
Academic Article	A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article	Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.
Academic Article	Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II.
Academic Article	Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
Academic Article	Identification and functional analysis of a novel mutation in the SOX10 gene associated with Waardenburg syndrome type IV.
Academic Article	Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.
Academic Article	Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma.
Academic Article	m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Grant	Discovering the epigenetics of RNA modifications
Grant	RNA methylation and regulatory T cells
Grant	Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant	Recognition and mechanism of N6-methyl adenosine modifications
Grant	Global Cysteine Modifications in Human Pathogens
Grant	Predoctoral Training Program in Chemistry and Biology - Renewal 01
Grant	Direct Oxidative Nucleic Acids Demethylation
Academic Article	Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Academic Article	Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells.

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genetic
pathways
leading
myeloid leukemias